Kineen Hotel S. Main St.	Town Hall S. Main St.	Bland Stables N. Main St.	Granit Building N. Main St.	Davis Store N. Main St.
Mayes Store S. Main St.	Store Front S. Lafayette St.	J. W. Rhodes House 35 S. Lafayette St.	C. E. Mayes House 39 S. Lafayette St.	R. J. Mayes House 40 S. Lafayette St.
Storage Buildings 34 S. Lafayette St.	W. D. Mayes House 15 Salem Ave.	Pack House 19 Salem Ave.	Grier House 24 Salem Ave.	McElveen House 112 Salem Ave.
Blackwell HOuse 113 Salem Ave.	North Lafayette St. Commercial Block	Bradley Store N. Lafayette St.	P. M. Tiller House 32 N. Lafayette St.	J. F. Bland House N. Lafayette St.

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The Mayesville Historic District is notable for its representation of the cultural, commercial, and architectural development of a small nineteenth century South Carolina community. The district, which encompasses the western half of the town, contains a concentration of eighty properties that represent a broad range of late nineteenth and early twentieth century vernacular architectural design, including commercial, residential (majority), and religious examples. Architectural styles include Neo-Classical, Victorian, Queen Anne, Colonial Revival, Commercial, and Bungalow. The visual appearance of the district reflects the evolution of this small rural town that developed as the result of the changing economic forces brought about by the establishment of rail transportation and subsequent commercialization in the late 1800s. Unfortunately, since its nomination many properties have been demolished or altered significantly. Listed in the National Register July 16, 1979.

View a map showing the boundaries of the Mayesville Historic District.