121-131 N. Main St.	135 N. Main St.	Moore and Sons 128 N. Main St.	J. B. Kelley Building 136 N. Main St.	People's Bank 140 N. Main St.
201-205 N. Main St.	207 N. Main St.	Windham Building 204 N. Main St.	Farmers Loan and Trust Company 210 N. Main St.	233 N. Main St.
Tisdale Building 243-247 N. Main St.	Seaboard Coastline Rail Depot N. Main St. and Cedar Lane	Palmetto Oil Company Cedar Lane

The Bishopville Commercial Historic District contains forty-eight contributing buildings which represent the historic commercial center of the community. All of the buildings are of brick construction with most constructed between 1890 and 1920. The buildings are all one to two stories in height and are vernacular commercial designs of the late nineteenth and early twentieth centuries. All of the buildings are used for commercial purposes such as stores, restaurants, offices and banks. Two important buildings, the Seaboard Coastline Depot and the Palmetto Oil Mill, are located adjacent to Main Street and are included in the district. The period of building reflects Bishopville’s period of prosperity and growth as a cotton shipping and trading center and as a county seat. By 1920 all of downtown was composed of substantial one to two-story brick buildings with detailing typical of the period. With the decline in the cotton industry after 1920, construction in the area came to a halt. Few changes have since occurred in the district. Listed in the National Register January 9, 1986.

View a map showing the boundaries of the Bishopville Commercial Historic District.